THE ROLE OF ENDOTHELIAL DYSFUNCTION IN INFLAMMATORY BOWEL DISEASES
نویسندگان
چکیده
The purpose of the study – to assess disorders’ degree endothelium dysfunction inpatients with nonspecific ulcerative colitis (NUC) and Crohn's disease (CD), dependingon severity inflammation.Material methods. 34 patients NUC 18 people CD continuousrecurrent courses, 15 in remission wereobserved. control group included 30 healthy volunteers.Results. It has been established that active had a significantly higherlevel markers characterizing changes proliferative (VEGF-165) adhesive(VCAM-1) endothelial functions vs. (in 4.62 2.01 times) whohad an inactive (at 3.95 4.62) (p<0.05). In course NUC, VEGF-165 level increased by 3.27 5.03 times, VCAM 1.83 2.09 times vs.inactive (p<0.05).In severe moderate degrees we have set increase theconcentration compared mild degree, p<0.05. proven thatin CD, concentration 21.5% moderateactivity 63.1% activity, p<0.05.It adhesive phenotype severeactivity was associated elevated content adhesion molecule, dependingof is proved forpatients activity p<0.05.We revealed reliable direct regression relationship between ofthe vascular growth factor UC according TrueloveWitts scale (R=0.29, p<0.05), CDAI index ofVCAM-1 p<0.05).Conclusions. Inflammatory bowel diseases - are accompanied withendothelium dysfunction, phenotypes, theactivity process.
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ژورنال
عنوان ژورنال: ???????? ?? ???????????????? ?????????
سال: 2021
ISSN: ['1727-4338', '2521-1153']
DOI: https://doi.org/10.24061/1727-4338.xx.2.76.2021.7